We have been studying L3MBTL1, a human homolog of the Drosophila lethal (3) malignant brain tumor (D l(3)mbt) polycomb protein, that functions as a tumor suppressor in the larval brain (Gateff et al., 1993; Wismar et al., 1995). Human L3MBTL1 is located on chromosome 20q within a regionlongchamp soldescommonly deleted in hematological malignancies (MacGrogan et al., 2004). L3MBTL1 contains three tandem MBT repeats (3xMBT), a C2HC zinc finger and an SPM oligomerization domain (Figure 1a).

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