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Because ProT secreting MBT 2 cells failed to result in tumors in immunocompetent syngeneic mice, it is suggested that local secretion of ProT from the tumor cells abrogated their tumorigenicity. It is of interest to examine whether in vivo administration of retroviruses expressing ProT can elicit cytotoxicfausse ugg pas cheractivity against tumor cells. To test whether the activity of lymphokine activated killer (LAK) cells can be enhanced in C3H/HeN mice coinjected with MBT 2 cells and retroviruses encoding ProT, spleen and lymph node cells were isolated from treated mice at 48 days after injection and cultured in the presence of IL 2 for 4 days.htt9.26

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